THE JEKYLL AND HYDE OF CELLULAR SENESCENCE IN CANCER

The Jekyll and Hyde of Cellular Senescence in Cancer

Cellular senescence is a state of stable cell cycle arrest that can be triggered in response to various insults and is characterized by distinct morphological hallmarks, gene expression profiles, and the senescence-associated secretory phenotype (SASP).Importantly, cellular senescence is a key component of normal physiology with tumor suppressive f

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Analytic salinity-temperature relations for the upper-thermocline waters of the eastern North Atlantic subtropical gyre

We study the dependence of salinity on temperature in two by two degrees latitude-longitude boxes, for surface and upper-thermocline waters of the Horns eastern North Atlantic subtropical gyre.The initial data set, from historical databases as well as from recent hydrographic cruises in the region, is carefully scrutinized to reject dubious measure

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Experiences from COVID-19 and Emergency Remote Teaching for Entrepreneurship Education in Engineering Programmes

Education systems and institutions, often historically considered to be resolute, slow-moving entities transformed virtually overnight during the earlier stages of the COVID-19 pandemic, demonstrating nimbleness in adversity.This paper describes the first-hand experiences of teaching staff and students from a UK university which pivoted to emergenc

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Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload.

BackgroundAXL is a receptor tyrosine kinase that has been related to kidney and vascular disorders.Heart failure patients with reduced ejection fraction have higher AXL in serum than controls.No information about Axl expression with HF progression is available.MethodsThoracic transverse aortic constriction (TAC) was successfully performed on male W

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